Understanding how von Willebrand Factor is processed in the blood
Mechanism underlying cofactor-dependent proteolysis of von Willebrand Factor
['FUNDING_R01'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11010808
This study is looking at how a protein called von Willebrand Factor works with another protein to help control blood clotting, which is important for people with bleeding disorders, and aims to find ways to prevent dangerous blood clots.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11010808 on ClinicalTrials.gov |
What this research studies
This research investigates the role of von Willebrand Factor (VWF) in blood clotting and how it is processed by a specific enzyme called ADAMTS13. The study focuses on the interaction between VWF and coagulation factor VIII, exploring how this interaction may help regulate the cleavage of VWF under mechanical stress. By using advanced molecular and biophysical techniques, researchers aim to uncover the mechanisms that control VWF processing, which is crucial for preventing dangerous blood clots. Patients with bleeding disorders may find this research particularly relevant as it seeks to improve our understanding of blood coagulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acquired von Willebrand disease or related bleeding disorders.
Not a fit: Patients with conditions unrelated to blood coagulation or those who do not have bleeding disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for patients with bleeding disorders, particularly those related to von Willebrand disease.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of blood coagulation, making this approach a continuation of established scientific inquiry.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHENG, X. LONG — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: ZHENG, X. LONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired von Willebrand disease, Acquired Von Willebrand syndrome