Understanding how voltage affects membrane transport in cells
Mechanisms of voltage regulation of membrane transport
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-11034139
This study is looking at how certain proteins in our cells help manage sodium and proton levels, which is important for conditions like ADHD, Angelman syndrome, and heart failure, to better understand how they work and what happens when they don't.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11034139 on ClinicalTrials.gov |
What this research studies
This research investigates the SLC9 family of membrane transporters, which play a crucial role in regulating the balance of sodium and protons in cells. By examining how voltage and cyclic nucleotides influence these transporters, the study aims to uncover the mechanisms behind their function and dysfunction. This could provide insights into various diseases linked to these transporters, including ADHD, Angelman syndrome, and heart failure. The research employs advanced biochemical and biophysical techniques to analyze the transport processes at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations related to SLC9 transporters, particularly those with ADHD, Angelman syndrome, or related disorders.
Not a fit: Patients without genetic mutations affecting SLC9 transporters or those not diagnosed with the related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions like ADHD and Angelman syndrome by targeting the underlying mechanisms of membrane transport dysfunction.
How similar studies have performed: Other research has shown promising results in understanding membrane transport mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOWDHURY, SANDIPAN — UNIVERSITY OF IOWA
- Study coordinator: CHOWDHURY, SANDIPAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Angelman Syndrome