Understanding how vitamin C transport is affected in Alzheimer's disease
Molecular mechanisms underlying reduced vitamin C transport process in Alzheimer's disease and its impact on neuroinflammation
This study is looking at how people with Alzheimer's disease may not get enough vitamin C and how that might lead to inflammation in the brain, with the goal of finding ways to help improve vitamin C absorption for better brain health in older adults.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11125200 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind reduced vitamin C transport in individuals with Alzheimer's disease (AD) and how this deficiency may contribute to neuroinflammation. The study focuses on the role of vitamin C as an antioxidant and its importance in brain health, particularly in older adults. Researchers will explore the expression of vitamin C transporters in the brain and intestines, examining how age and inflammation may impact their function. By understanding these processes, the research aims to identify potential therapeutic targets for improving vitamin C absorption in AD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with Alzheimer's disease who may be experiencing vitamin C deficiency.
Not a fit: Patients without Alzheimer's disease or those who do not have issues related to vitamin C absorption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing vitamin C levels in Alzheimer's patients, potentially slowing disease progression and reducing inflammation.
How similar studies have performed: Previous research has indicated the importance of vitamin C in brain health, but this specific investigation into its transport mechanisms in Alzheimer's disease is relatively novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Subramanian, Veedamali S — University of California-Irvine
- Study coordinator: Subramanian, Veedamali S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.