Understanding how vitamin B12 affects the development of certain cells in the body.
Official title: THE ROLE OF VITAMIN B12-DEPENDENT METABOLIC PATHWAYS IN NEURAL CREST DEVELOPMENT
Funded at Baylor College of Medicine · NIH-11018849 · Data updated 2026-11-12
This study is looking at how vitamin B12 affects the development of important cells in the body, which can help us understand certain birth defects, and it aims to find new ways to help people who have conditions related to vitamin B12.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | June 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $534,899 |
| NIH project number | 1R01HD116761-01 |
| Project ID | NIH-11018849 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital malformations related to neural crest cell development, particularly those with cobalamin metabolism disorders.
✕Less likely to help
Patients without any congenital malformations or those not affected by vitamin B12 metabolism disorders may not benefit from this research.
What this research studies
This research investigates the role of vitamin B12-dependent metabolic pathways in the development of neural crest cells, which are crucial for forming various tissues and organs in the body. The study aims to explore how disruptions in these pathways can lead to congenital malformations known as neurocristopathies. By focusing on a specific genetic condition related to vitamin B12 metabolism, the researchers hope to uncover the cellular and molecular mechanisms that could lead to new therapeutic targets for affected individuals. Patients may benefit from insights into how vitamin B12 impacts their development and potential treatments for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for congenital disorders linked to vitamin B12 metabolism.
How similar studies have gone: Previous research has shown promising results in understanding the role of metabolic pathways in developmental disorders, suggesting potential for success in this area.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Poche, Ross Anthony — Baylor College of Medicine
- Study coordinator: Poche, Ross Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.