Understanding how visual signals are processed in the retina
Synaptic mechanisms and circuitry of retinal interneurons
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11060041
This study is looking at how signals from light are passed through different cells in the retina, which is important for vision, and it's designed for anyone interested in understanding how our eyes work better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11060041 on ClinicalTrials.gov |
What this research studies
This research investigates the transmission of visual signals from the outer to the inner retina, focusing on the synaptic mechanisms and circuits involving cone bipolar cells and their connections to ganglion and amacrine cells. Using advanced techniques like dual patch-clamp recording and two-photon optical imaging, the study aims to correlate the anatomical structure of these cells with their physiological functions. By examining these interactions in the mouse retina, the research seeks to fill gaps in our understanding of retinal processing and how visual information is relayed to the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with retinal disorders or those interested in the biological mechanisms of vision.
Not a fit: Patients with conditions unrelated to retinal function or those not experiencing visual processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for retinal disorders and enhance our understanding of visual processing.
How similar studies have performed: Other research has shown success in understanding retinal circuitry and synaptic mechanisms, indicating that this approach is building on established findings.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, Z JIMMY — YALE UNIVERSITY
- Study coordinator: ZHOU, Z JIMMY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.