Understanding how VISTA affects triple-negative breast cancer
Molecular mechanisms and therapeutic principles of VISTA+ triple-negative breast cancers
This study is looking at how a specific immune receptor called VISTA affects triple-negative breast cancer, with the goal of finding new ways to make treatments work better for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11056845 on NIH RePORTER |
What this research studies
This research investigates the role of the immune receptor VISTA in triple-negative breast cancer (TNBC), a particularly aggressive form of cancer. The study aims to uncover how VISTA influences the behavior of cancer cells and their interaction with the immune system. By analyzing the molecular mechanisms behind VISTA's function, researchers hope to identify new therapeutic targets that could enhance the effectiveness of existing treatments. Patients may benefit from insights that could lead to improved immunotherapy strategies for TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple-negative breast cancer, particularly those whose tumors overexpress the VISTA receptor.
Not a fit: Patients with non-triple-negative breast cancers or those without VISTA overexpression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with triple-negative breast cancer.
How similar studies have performed: Other research has shown promising results in targeting similar immune receptors, suggesting that this approach may yield significant advancements in treatment.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Gruber, Joshua James — Ut Southwestern Medical Center
- Study coordinator: Gruber, Joshua James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.