Understanding how viruses use a specific RNA modification to affect their behavior
Employing viruses to unravel the functional significance of the m5C epitranscriptome
This study is looking at how a special change in RNA called 5-methylcytosine affects certain viruses, like Sindbis and chikungunya, to help us understand how they grow and interact with our bodies, which could lead to new treatments for viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11010851 on NIH RePORTER |
What this research studies
This research investigates the role of 5-methylcytosine (m5C), a specific modification of RNA, in various RNA viruses. By utilizing advanced techniques such as high-throughput sequencing and animal models, the study aims to uncover how m5C influences viral replication and interactions with host cells. The research focuses on specific viruses like Sindbis and chikungunya, exploring how this modification affects their life cycles and pathogenicity. Patients may benefit from insights gained that could lead to new antiviral therapies targeting these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals affected by viral infections, particularly those caused by Sindbis virus, chikungunya virus, or Coxsackievirus B3.
Not a fit: Patients with non-viral related conditions or those not infected by the specific viruses studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral treatments that specifically target viral RNA modifications.
How similar studies have performed: While the role of m5C in tRNA biology is well-established, the exploration of its significance in viral RNA is relatively novel, indicating potential for groundbreaking findings.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Rice, Charles M — Rockefeller University
- Study coordinator: Rice, Charles M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.