Understanding how viruses manipulate DNA repair and replication in cells
Official title: Defining how cellular DNA replication and repair machinery are hijacked by viral pathogens
Funded at University of Wisconsin-Madison · NIH-10938632 · Data updated 2026-11-12
This study looks at how viruses take over the parts of our cells that help fix DNA, which is important for keeping our cells healthy, and the findings could help create new treatments for viral infections and related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 10, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $375,430 |
| NIH project number | 1R35GM154938-01 |
| Project ID | NIH-10938632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with viral infections or conditions related to DNA damage and repair.
✕Less likely to help
Patients with non-viral related conditions or those not affected by DNA repair issues may not receive benefits from this research.
What this research studies
This research investigates how viral pathogens exploit the cellular machinery responsible for DNA replication and repair. By examining the interactions between viruses and host DNA repair proteins, the study aims to uncover the mechanisms that allow viruses to hijack these critical processes. The approach involves developing novel tools and technologies to analyze how viruses affect genome stability, which is essential for maintaining healthy cells. Patients may benefit from insights gained in this research that could lead to new therapeutic strategies against viral infections and related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to combat viral infections and improve genome stability.
How similar studies have gone: Other research has shown success in understanding viral manipulation of cellular processes, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Majumder, Kinjal — University of Wisconsin-Madison
- Study coordinator: Majumder, Kinjal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.