Understanding how viruses interact with the host's immune system
Overcoming host Genetic Redundancy and Pathogen Subversion to Define new host-viral Interfaces
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10877892
This study is looking at how viruses interact with our immune system to find new ways to help our bodies fight infections better, and it's for anyone interested in understanding more about how we can improve treatments for viral diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10877892 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between viruses and the host's immune defenses. By using a new genetic screening platform, the team aims to identify antiviral genes that can be targeted to enhance the host's ability to fight infections. The study focuses on both virulent and weakened strains of viruses to uncover how they evade the immune response. This approach could lead to new insights into infectious diseases and potential therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with viral infections or those at risk of developing such infections.
Not a fit: Patients with non-viral infections or those who do not have a compromised immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response against viral infections.
How similar studies have performed: Other research has shown success in identifying host-pathogen interactions, but this approach using genetic screening to bypass redundancy is relatively novel.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ORCHARD, ROBERT C. — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: ORCHARD, ROBERT C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Communicable Diseases