Understanding how viruses interact with host defenses
Official title: Interplay between reverse transcription and host restriction
Funded at University of Illinois at Chicago · NIH-11083095 · Data updated 2026-11-12
This study looks at how certain viruses interact with mammals, especially how our bodies fight off these viruses and how the viruses try to outsmart our defenses, with the goal of finding new ways to help people better manage viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | June 14, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $518,433 |
| NIH project number | 5R01AI174538-03 |
| Project ID | NIH-11083095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with viral infections, particularly those affected by retroviruses like HIV.
✕Less likely to help
Patients with non-viral related conditions or those not affected by retroviral infections may not receive any benefit from this research.
What this research studies
This research investigates the complex relationship between retroviruses and their mammalian hosts, focusing on how hosts suppress viral replication and how viruses adapt to these defenses. Using murine leukemia virus as a model, the study explores the role of specific proteins that can block viral replication or alter the viral genome. By examining the mechanisms of viral restriction and host responses, the research aims to uncover new insights into viral infections and potential therapeutic strategies. Patients may benefit from a deeper understanding of how their immune systems can be harnessed to combat viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response against viral infections, particularly in patients with compromised immune systems.
How similar studies have gone: Previous research has shown success in understanding host-virus interactions, indicating that this approach has potential for meaningful advancements in treatment.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Ross, Susan R — University of Illinois at Chicago
- Study coordinator: Ross, Susan R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.