Understanding how viruses influence immunity in the female reproductive system
Uncovering the role of endogenous retroviruses in shaping antiviral immunity of the female reproductive tract
['FUNDING_OTHER'] · U.S. NATIONAL INST ON DEAFNESS/COMM DISR · NIH-10711152
This study is looking at how certain viruses and the bacteria in the vagina work together to help protect women's reproductive health and fight off infections, especially for those using antibiotics or medications for HIV.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | U.S. NATIONAL INST ON DEAFNESS/COMM DISR (nih funded) |
| Locations | 1 site (BETHESDA, UNITED STATES) |
| Trial ID | NIH-10711152 on ClinicalTrials.gov |
What this research studies
This research investigates the role of endogenous retroviruses and vaginal microbiota in shaping the immune response of the female reproductive tract (FRT). It aims to uncover how these factors interact to control viral infections while maintaining reproductive health. By analyzing immune cell populations and functions in the FRT, the study seeks to understand the mechanisms that influence susceptibility to infections, particularly in women using antibiotics or anti-retroviral medications. The research employs a combination of epidemiological data and laboratory analysis to explore these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are concerned about viral infections and those who have used antibiotics or anti-retroviral medications.
Not a fit: Patients who do not have a female reproductive system or those not affected by viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing viral infections in women, enhancing reproductive health.
How similar studies have performed: While the role of microbiota in immunity has been studied, the specific focus on endogenous retroviruses in the female reproductive tract is relatively novel and has not been extensively tested.
Where this research is happening
BETHESDA, UNITED STATES
- U.S. NATIONAL INST ON DEAFNESS/COMM DISR — BETHESDA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEGRIST, ELISHA — U.S. NATIONAL INST ON DEAFNESS/COMM DISR
- Study coordinator: SEGRIST, ELISHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus