Understanding how viruses infect cells and the body's response
An integrative, data-driven, and computational approach to uncovering dynamic mechanisms of early viral infection
This study is looking at how viruses start to infect the body and how our immune system responds, especially when there are no symptoms, to help us understand the infection better and find important genes that could play a role in this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10893035 on NIH RePORTER |
What this research studies
This research investigates the early stages of viral infection and how the body responds to it by using advanced computational tools and algorithms. It aims to analyze large datasets generated from biological processes to uncover the mechanisms of viral infection, particularly focusing on the asymptomatic phase where the virus replicates without symptoms. By integrating data from various biological models and employing techniques like CRISPR and machine learning, the research seeks to identify key genes involved in the infection process. This could lead to a better understanding of how infections progress and how the body reacts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of viral infections or those who have experienced recent viral infections.
Not a fit: Patients with established viral infections showing severe symptoms may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating viral infections by targeting the early stages of infection.
How similar studies have performed: Other research has shown promise in using computational approaches to understand viral infections, suggesting that this method could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Van Dijk, David — Yale University
- Study coordinator: Van Dijk, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.