Understanding how viruses fuse with cells
Biophysical studies of viral membrane fusion proteins
This study is looking at how viruses like the one that causes COVID-19 connect with our cells, using a part of the flu virus to help understand the process better, which could lead to new ways to treat viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10885026 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which certain viruses, including the SARS-CoV-2 virus responsible for COVID-19, fuse with human cells. By studying a model viral protein called hemagglutinin from the Influenza A virus, the researchers aim to uncover the detailed steps and changes that occur during the fusion process. This involves examining how viral proteins interact with cell membranes and the conformational changes that facilitate this interaction. The findings could lead to a better understanding of viral infections and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of viral infections, particularly those related to coronaviruses and influenza.
Not a fit: Patients who are not affected by viral infections or who have already been vaccinated against these viruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating viral infections, including COVID-19.
How similar studies have performed: Other research has shown success in understanding viral fusion mechanisms, making this approach both relevant and promising.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Munro, James B — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Munro, James B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.