Understanding how viruses fuse with cell membranes
Official title: Advancing our knowledge of viral membrane fusion and of IDP-membrane interactions by ESR
Funded at Cornell University · NIH-11013889 · Data updated 2026-11-12
This study is looking at how viruses like the coronavirus and HIV enter our cells, focusing on the role of calcium in this process, to help find new ways to treat infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $369,000 |
| NIH project number | 5R35GM148272-03 |
| Project ID | NIH-11013889 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by viral infections, particularly those with COVID-19 or HIV.
✕Less likely to help
Patients with non-viral related health issues or those not affected by the viruses being studied may not benefit from this research.
What this research studies
This research investigates the mechanisms by which viruses, including the novel coronavirus and HIV, fuse with cell membranes, a critical step in viral infection. Using advanced electron-spin resonance (ESR) techniques, the study aims to explore the interactions between viral proteins and cell membranes, particularly focusing on the role of calcium ions in this process. By combining ESR with other biophysical methods, the research seeks to uncover the fundamental processes that enable viral entry into host cells, which could inform the development of new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent viral infections by targeting the fusion process.
How similar studies have gone: Previous research has shown promising results in understanding viral membrane fusion, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Freed, Jack H — Cornell University
- Study coordinator: Freed, Jack H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.