Understanding how viruses enter the nucleus of human cells
Hijacking host cellular motors for the nuclear entry of polyomaviruses
This study is looking at how certain viruses, which can lead to serious illnesses like skin cancer, move inside our cells and how we might be able to stop them, so it could help patients find better treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10868562 on NIH RePORTER |
What this research studies
This research investigates how polyomaviruses, which can cause serious diseases like Merkel cell carcinoma, navigate through human cells to reach the nucleus. The study focuses on the role of cellular motor proteins, specifically kinesin and dynein, in transporting these viruses within the crowded cellular environment. By examining the mechanisms of viral entry and transport, the research aims to uncover critical steps that could lead to new therapeutic strategies. Patients may benefit from insights gained about how these viruses operate and how to potentially block their harmful effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers associated with polyomavirus infections, such as Merkel cell carcinoma.
Not a fit: Patients with cancers not linked to polyomavirus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers caused by polyomaviruses.
How similar studies have performed: Previous research has shown that understanding viral mechanisms can lead to significant advancements in treatment, indicating potential success for this approach.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Spriggs, Chelsey Cierra — University of Michigan at Ann Arbor
- Study coordinator: Spriggs, Chelsey Cierra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.