Understanding How Viruses Enter Human Cells
DMS/NIGMS 2: Integrated Analysis of Fusion Protein Conformational Changes for Virus Entry
This research explores how viruses like HIV and the one causing COVID-19 get inside human cells to cause infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project ID | NIH-11146507 on NIH RePORTER |
What this research studies
Virus infections continue to be a major health concern worldwide, and all enveloped viruses must fuse with host cells to begin an infection. This project aims to uncover the detailed structural changes in viral proteins that allow them to merge with human cell membranes. By combining advanced computer modeling, machine learning, and laboratory experiments, we hope to map out these complex steps. We are using the herpes simplex virus as a model to understand these fundamental processes, which could apply to many other viruses.
Who could benefit from this research
Good fit: This foundational research is relevant to patients affected by viral infections, including those caused by HIV, SARS-CoV-2, and herpesviruses.
Not a fit: Patients whose conditions are not related to viral infections or the mechanisms of viral entry would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for developing antiviral medications that prevent viruses from entering and infecting human cells.
How similar studies have performed: This project builds upon decades of experience in virology and membrane fusion, integrating novel multiscale modeling and machine learning techniques with established experimental methods.
Where this research is happening
Pullman, United States
- Washington State University — Pullman, United States (Active)
Researchers
- Principal investigator: Liu, Jin — Washington State University
- Study coordinator: Liu, Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.