Understanding how viruses change to create new ways to fight infections
Defining the viral PTMome: Towards the development of novel antiviral approaches
['FUNDING_OTHER'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11136419
This work explores how viruses like HIV and influenza modify their proteins to find new ways to stop them from causing illness.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11136419 on ClinicalTrials.gov |
What this research studies
Traditional antiviral medicines often target the virus directly, but viruses can quickly change and become resistant to these treatments. This project aims to discover new ways to fight viral infections by focusing on how human cells interact with viral proteins. By understanding these interactions, we hope to develop treatments that are harder for viruses to escape and that could work against many different types of viruses, including those that might emerge in the future. This creative approach could lead to more effective and lasting protection against infectious diseases.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical trials stemming from this work would target individuals with viral infections like HIV or influenza.
Not a fit: Patients not currently affected by viral infections or those seeking immediate treatment options would not directly benefit from this early-stage research.
Why it matters
Potential benefit: If successful, this research could lead to the development of entirely new types of antiviral drugs that are more effective and less prone to viral resistance.
How similar studies have performed: While traditional antiviral approaches have been successful, the strategy of targeting host-virus interactions to overcome viral resistance is a novel and less explored area with promising potential.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GACK, MICHAELA ULRIKE — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: GACK, MICHAELA ULRIKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Communicable Diseases