Understanding how viruses and bacteria interact with humans during health disruptions
Functional characterization of viral-bacterial-human interactions during antimicrobial and inflammatory perturbations across different lifespans
['FUNDING_U01'] · WASHINGTON UNIVERSITY · NIH-10987988
This study is looking at how viruses and bacteria in our gut interact and how things like antibiotics and inflammation can change those relationships, using a large number of stool samples to help us understand how these changes affect our health.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10987988 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between viruses, bacteria, and human health, particularly focusing on how these relationships are affected by antibiotics and inflammation. By analyzing over 70,000 stool samples from diverse patient cohorts, the study aims to uncover the mechanisms that govern the resilience of the gut microbiome during various health challenges. The research will explore how changes in viral communities can influence bacterial populations and human health outcomes, providing insights into the gut's role in overall well-being.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of all ages who have experienced antibiotic treatment or inflammatory conditions affecting their gut health.
Not a fit: Patients who have not undergone antibiotic treatment or do not have any inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing gut health and mitigating the negative effects of antibiotics and inflammation.
How similar studies have performed: Previous research has shown promising results in understanding the role of the gut microbiome in health, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DANTAS, GAUTAM — WASHINGTON UNIVERSITY
- Study coordinator: DANTAS, GAUTAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.