Understanding how viruses adapt by interacting with host cell proteins
Defining the Interplay Between Viral Adaptation and Host Proteostasis
This study looks at how viruses like the flu change and survive by working with our body's proteins, which help them grow and avoid our immune system, and the findings could help create better treatments for viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10909143 on NIH RePORTER |
What this research studies
This research investigates how RNA viruses, like influenza, adapt to their environment by interacting with the host cell's protein folding machinery. It explores the role of host chaperones in helping viral proteins fold correctly, which may enhance the virus's ability to evade the immune system and resist antiviral treatments. By using advanced techniques in chemical biology, genetics, and computational modeling, the study aims to uncover the molecular mechanisms that govern this interaction. Patients may benefit from insights gained that could lead to improved antiviral therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with RNA viruses, particularly those with influenza or similar viral infections.
Not a fit: Patients with non-RNA viral infections or those not currently infected with any virus may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antiviral treatments for diseases caused by RNA viruses.
How similar studies have performed: Previous research has shown promising results in understanding viral adaptation through host interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Shoulders, Matthew Donald — Massachusetts Institute of Technology
- Study coordinator: Shoulders, Matthew Donald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.