Understanding how viral proteins evolve to bind to new targets
Official title: Molecular determinants of viral receptor-binding protein evolution; innovation, constraints, and evolvability
Funded at University of California, San Diego · NIH-11090093 · Data updated 2026-11-12
This study is looking at how certain proteins in a virus called bacteriophage λ change over time and how they interact with the bacteria E. coli, which could help us understand how viruses evolve and might lead to new uses in technology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 5, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $380,725 |
| NIH project number | 1R35GM158099-01 |
| Project ID | NIH-11090093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions related to viral infections or those interested in the mechanisms of viral evolution.
✕Less likely to help
Patients with non-viral related conditions or those not affected by bacteriophage interactions may not receive any benefit from this research.
What this research studies
This research investigates the evolution of receptor-binding proteins (RBPs) in bacteriophage λ and their interactions with Escherichia coli. By analyzing genetic mutations and their effects on protein structure and function, the study aims to uncover the molecular mechanisms that allow these proteins to adapt and gain new functions. The approach involves creating extensive genetic libraries and examining how specific mutations influence the binding capabilities of RBPs. This research could provide insights into viral evolution and potential applications in biotechnology.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding viral adaptability, which may inform the development of new therapeutic strategies against viral infections.
How similar studies have gone: Previous research has successfully explored the evolution of viral proteins, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Meyer, Justin Raymond — University of California, San Diego
- Study coordinator: Meyer, Justin Raymond
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.