Understanding how viral proteins affect cell function and gene expression
Official title: Dissecting the Impact of Viral Biomolecular Condensates on Cellular Translation and RNA Interference (RNAi)
Funded at University of Missouri Kansas City · NIH-10939649 · Data updated 2026-11-12
This study is looking at how certain structures formed by viruses inside plant cells can change how those cells work and respond to infection, which could help us find new ways to treat viral infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri Kansas City NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 10, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $386,843 |
| NIH project number | 1R35GM154909-01 |
| Project ID | NIH-10939649 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by viral infections or those interested in understanding the cellular mechanisms involved in viral pathogenesis.
✕Less likely to help
Patients with non-viral related conditions or those not affected by viral infections may not benefit from this research.
What this research studies
This research investigates how viral biomolecular condensates, which are structures formed within cells, influence cellular processes and the translation of RNA. By using model plant viruses, the study aims to uncover the mechanisms through which these viral condensates disrupt normal cellular functions and affect the host's response to infection. The research employs advanced techniques like nanopore sequencing and transcriptome-wide methodologies to analyze the impact of these condensates on gene expression during viral infections. This work could provide insights into the interactions between viruses and host cells, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to fight viral infections.
How similar studies have gone: Other research has shown promise in understanding viral interactions with host cells, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Missouri Kansas City
Kansas City, United States Active
Researchers
- Principal investigator: May, Jared Paul — University of Missouri Kansas City
- Study coordinator: May, Jared Paul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.