Understanding how viral proteins affect cell function and gene expression
Dissecting the Impact of Viral Biomolecular Condensates on Cellular Translation and RNA Interference (RNAi)
['FUNDING_OTHER'] · UNIVERSITY OF MISSOURI KANSAS CITY · NIH-10939649
This study is looking at how certain structures formed by viruses inside plant cells can change how those cells work and respond to infection, which could help us find new ways to treat viral infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSOURI KANSAS CITY (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10939649 on ClinicalTrials.gov |
What this research studies
This research investigates how viral biomolecular condensates, which are structures formed within cells, influence cellular processes and the translation of RNA. By using model plant viruses, the study aims to uncover the mechanisms through which these viral condensates disrupt normal cellular functions and affect the host's response to infection. The research employs advanced techniques like nanopore sequencing and transcriptome-wide methodologies to analyze the impact of these condensates on gene expression during viral infections. This work could provide insights into the interactions between viruses and host cells, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by viral infections or those interested in understanding the cellular mechanisms involved in viral pathogenesis.
Not a fit: Patients with non-viral related conditions or those not affected by viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to fight viral infections.
How similar studies have performed: Other research has shown promise in understanding viral interactions with host cells, suggesting that this approach could yield valuable insights.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF MISSOURI KANSAS CITY — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAY, JARED PAUL — UNIVERSITY OF MISSOURI KANSAS CITY
- Study coordinator: MAY, JARED PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.