Understanding how vimentin helps cells move together in 3D environments
Mechanobiology of Vimentin Intermediate Filaments in 3D Collective Cell Migration
['FUNDING_R01'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-10987039
This study looks at how a protein called vimentin helps groups of cells move together, which is important for healing wounds and developing embryos, to better understand how cells work together in our bodies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10987039 on ClinicalTrials.gov |
What this research studies
This research investigates the role of vimentin intermediate filaments in the collective migration of cells, which is essential for processes like wound healing and embryonic development. By studying how vimentin influences the movement and coordination of groups of cells, the research aims to uncover mechanisms that allow cells to migrate together effectively. The approach involves examining the interactions between vimentin and other cellular components, such as cell-cell junctions, to understand how these factors contribute to cell motility in three-dimensional settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve impaired wound healing or cancer metastasis.
Not a fit: Patients with conditions unrelated to cell migration or those not undergoing treatments that affect vimentin expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing wound healing and targeting tumor invasiveness.
How similar studies have performed: Previous research has shown promising results in understanding cell migration mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUO, MING — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: GUO, MING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.