Understanding how Vibrio cholerae transfers genes to other bacteria
Mechanisms and regulation of horizontal gene transfer by natural transformation in Vibrio cholerae
This study is looking at how the cholera-causing bacteria can share genes with other bacteria, especially when they form slimy layers on shells of small sea creatures, to understand how this might help bacteria become resistant to antibiotics and more harmful, which could lead to better ways to fight these tough infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10844560 on NIH RePORTER |
What this research studies
This research investigates how the bacterium Vibrio cholerae, which causes cholera, transfers genetic material to other bacteria through a process called natural transformation. The study focuses on the mechanisms and regulation of this gene transfer, particularly in environments where V. cholerae forms biofilms on crustacean shells. By using advanced genetic tools and laboratory models, the researchers aim to uncover how this process contributes to the spread of antibiotic resistance and virulence factors among bacteria. The findings could lead to new strategies for combating infections caused by antibiotic-resistant bacteria.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals affected by infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with non-bacterial infections or those not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights and strategies to combat antibiotic-resistant infections.
How similar studies have performed: Other research has shown success in understanding gene transfer mechanisms in bacteria, indicating that this approach has potential for significant findings.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Dalia, Ankur — Trustees of Indiana University
- Study coordinator: Dalia, Ankur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.