Understanding how very preterm infants respond to different treatments
Official title: Early Life Phenotyping of Very Preterm Infants
Funded at Children's Hosp of Philadelphia · NIH-10809386 · Data updated 2026-11-12
This study is looking at how different factors, like delivery methods and care practices, affect the health of very preterm babies born before 32 weeks, so we can find better ways to support their treatment and care.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $178,000 |
| NIH project number | 1R03HD111747-01A1 |
| Project ID | NIH-10809386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are very preterm infants born at or before 32 weeks of gestation.
✕Less likely to help
Patients who are not very preterm infants or those born after 32 weeks of gestation may not benefit from this research.
What this research studies
This research investigates the factors that influence how very preterm infants, born at or before 32 weeks of gestation, respond to various therapies. By examining the perinatal period, the study aims to identify specific characteristics and experiences that can help tailor treatments for these vulnerable infants. The research will analyze data related to delivery methods, maternal care practices, and the use of antibiotics to better understand their impact on infant health outcomes. Ultimately, the goal is to improve the care and treatment of very preterm infants by recognizing their unique needs.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for very preterm infants, potentially improving their survival and long-term health outcomes.
How similar studies have gone: Previous research has shown that understanding individual responses to treatment in preterm infants can lead to improved care, indicating that this approach has potential for success.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Mukhopadhyay, Sagori — Children's Hosp of Philadelphia
- Study coordinator: Mukhopadhyay, Sagori
Related research
Other NIH-funded projects on the same topics.
-
Screening and treatment of Chlamydia infection in pregnancy to help prevent preterm birth
This grant studies whether screening pregnant people for Chlamydia trachomatis and treating those who are positive can reduce the risk of preterm birth.
-
Preterm infant body composition and early-life health after NICU stay
This grant studies how body composition in very preterm babies relates to later brain development and risk of obesity or diabetes, with findings meant to improve care from NICU through early childhood.
-
Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains
This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.
-
Xylitol to Prevent Periodontal Disease and Preterm Birth in Pregnancy and Early Childhood
A safe, inexpensive chewable gum approach using xylitol is tested to help pregnant people reduce gum disease and lower the chance of preterm birth and related child health problems.
-
Screening and treatment for Chlamydia infection to help prevent preterm birth
A study in pregnant people will test whether screening for Chlamydia trachomatis and treating it during pregnancy can reduce the risk of babies being born too early.
-
PREEMIE PROGRESS: a family program to help parents of very preterm babies
A family-centered program that teaches parents how to care for very preterm infants, offers psychosocial support, and connects families with resources to address social needs.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.