Understanding how very long chain fatty acids affect protein quality and cell membranes
Role of very long chain fatty acids in protein quality control and membrane homeostasis
This study is looking at how certain fats in our bodies help keep our cells healthy and stable, especially when proteins don’t fold correctly, which can happen in diseases like cancer and metabolic disorders, so that patients can learn more about how these fats might affect their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10674479 on NIH RePORTER |
What this research studies
This research investigates the role of very long chain fatty acids (VLCFAs) in maintaining protein quality and the stability of cell membranes. It focuses on how cells respond to misfolded proteins and the importance of lipid balance in this process. By studying specific genetic mutations that affect VLCFA utilization, the research aims to uncover the mechanisms by which these lipids influence cellular stress responses and membrane dynamics. Patients may benefit from insights into how these processes relate to various diseases, including cancers and metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with metabolic disorders, cancers, or conditions related to protein misfolding.
Not a fit: Patients with conditions unrelated to lipid metabolism or protein quality control may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing conditions related to protein misfolding and membrane dysfunction.
How similar studies have performed: Other research has shown promising results in understanding lipid roles in cellular processes, suggesting potential for success in this area.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hanna, John W — Brigham and Women's Hospital
- Study coordinator: Hanna, John W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.