Understanding how vertebrates maintain left-right body symmetry during development
Dynamical maintenance of left-right symmetry during vertebrate development
['FUNDING_R01'] · BRANDEIS UNIVERSITY · NIH-11098154
This study looks at how animals, like mice, develop their bodies to be symmetrical and how this process can go wrong, which might help us understand conditions like scoliosis better and improve treatments for people with similar issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRANDEIS UNIVERSITY (nih funded) |
| Locations | 1 site (WALTHAM, UNITED STATES) |
| Trial ID | NIH-11098154 on ClinicalTrials.gov |
What this research studies
This research investigates how vertebrates develop and maintain left-right symmetry, which is crucial for proper bodily functions. By studying wild-type mice and those with induced asymmetry, the project combines biological experiments with mathematical modeling to explore the role of retinoic acid in somite formation. The research aims to uncover the mechanisms that ensure symmetrical development, which could lead to insights into congenital abnormalities like scoliosis. Patients may benefit from a better understanding of these processes, potentially leading to improved treatments for related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities affecting body symmetry, such as scoliosis.
Not a fit: Patients with conditions unrelated to developmental symmetry or those who have already undergone corrective procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for congenital abnormalities related to body asymmetry.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown success in understanding developmental processes and their implications for congenital defects.
Where this research is happening
WALTHAM, UNITED STATES
- BRANDEIS UNIVERSITY — WALTHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOUBOUL, JONATHAN DAVID — BRANDEIS UNIVERSITY
- Study coordinator: TOUBOUL, JONATHAN DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.