Understanding how venous congestion affects organ function and outcomes in sepsis patients
Official title: Profiles and impact of venous congestion on organ function and patient outcomes in sepsis
Funded at Wayne State University · NIH-11088875 · Data updated 2026-11-12
This study is looking at how blood flow problems affect organ health and recovery in people with sepsis, using special imaging and tests to better understand each patient's needs so that treatments can be more personalized.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $385,000 |
| NIH project number | 5R35GM151107-03 |
| Project ID | NIH-11088875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients presenting with sepsis in the Emergency Department, particularly those with varying degrees of cardiac dysfunction.
✕Less likely to help
Patients who do not have sepsis or those with stable conditions unrelated to venous congestion may not benefit from this research.
What this research studies
This research investigates the impact of venous congestion on organ function and patient outcomes in individuals suffering from sepsis. By utilizing a combination of sonographic imaging and biomarker analysis, the study aims to identify distinct patient profiles at the time of their presentation to the Emergency Department and throughout their hospitalization. This approach seeks to create a detailed database that can help tailor treatments to individual patient needs, moving away from one-size-fits-all strategies. The research will explore how factors like cardiac dysfunction and intravenous fluid administration can worsen venous congestion and its effects on vital organs.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for sepsis patients, potentially reducing mortality and improving recovery outcomes.
How similar studies have gone: While there have been numerous studies on sepsis, this approach of identifying septic phenotypes through biomarker and imaging data is relatively novel and has not been extensively tested.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Ehrman, Robert Russell — Wayne State University
- Study coordinator: Ehrman, Robert Russell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.