Understanding how vascular calcification occurs in chronic kidney disease
Official title: The transcriptional control of vascular calcification in disease
Funded at University of Colorado Denver · NIH-11038002 · Data updated 2026-11-12
This study is looking into how certain fatty acids, like stearic acid, can lead to hardening of the blood vessels in people with chronic kidney disease, and it hopes to find new ways to prevent this problem to help improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | March 15, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $563,446 |
| NIH project number | 5R01HL157064-03 |
| Project ID | NIH-11038002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from chronic kidney disease who are at risk of developing vascular calcification.
✕Less likely to help
Patients without chronic kidney disease or those not experiencing vascular calcification may not benefit from this research.
What this research studies
This research investigates the mechanisms behind vascular calcification, a serious complication in patients with chronic kidney disease (CKD). It focuses on how certain fatty acids, particularly stearic acid, contribute to this condition by affecting vascular smooth muscle cells. The study aims to identify new pharmacological strategies to prevent vascular calcification by exploring the biochemical pathways involved in this process. Patients may benefit from insights that could lead to effective therapies for managing vascular calcification.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent vascular calcification in patients with chronic kidney disease.
How similar studies have gone: Previous studies have shown promising results in understanding the biochemical pathways involved in vascular calcification, suggesting that this approach may lead to significant advancements.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Miyazaki, Makoto — University of Colorado Denver
- Study coordinator: Miyazaki, Makoto
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.