Understanding how vascular calcification affects heart disease
Vascular calcification and atherosclerosis
['FUNDING_R01'] · NEW YORK INST OF TECHNOLOGY · NIH-11001109
This study is looking at how hardening of the arteries, known as vascular calcification, might increase the risk of heart disease, and it aims to find new ways to treat or prevent this condition that could help patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK INST OF TECHNOLOGY (nih funded) |
| Locations | 1 site (OLD WESTBURY, UNITED STATES) |
| Trial ID | NIH-11001109 on ClinicalTrials.gov |
What this research studies
This research investigates the role of vascular calcification as a risk factor for cardiovascular disease (CVD), which is the leading cause of death in the U.S. The study explores how calcification may contribute to the development and progression of atherosclerosis, a condition characterized by the buildup of plaques in the arteries. By examining the effects of tissue-nonspecific alkaline phosphatase (TNAP) and its inhibitors in both animal models and human arteries, the research aims to uncover potential pathways for treatment and prevention. Patients may benefit from insights that could lead to new therapeutic strategies targeting vascular calcification.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for cardiovascular disease, particularly those with existing conditions related to atherosclerosis.
Not a fit: Patients with non-cardiovascular related health issues or those without risk factors for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart disease by targeting vascular calcification.
How similar studies have performed: Other research has shown promising results in understanding the relationship between vascular calcification and atherosclerosis, suggesting that this approach could yield significant insights.
Where this research is happening
OLD WESTBURY, UNITED STATES
- NEW YORK INST OF TECHNOLOGY — OLD WESTBURY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAVINOVA, OLGA V. — NEW YORK INST OF TECHNOLOGY
- Study coordinator: SAVINOVA, OLGA V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.