Understanding how vascular calcification affects heart disease
Official title: Vascular calcification and atherosclerosis
Funded at New York Inst of Technology · NIH-11001109 · Data updated 2026-11-12
This study is looking at how hardening of the arteries, known as vascular calcification, might increase the risk of heart disease, and it aims to find new ways to treat or prevent this condition that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Inst of Technology NIH-funded |
| Lab location | 1 site (Old Westbury, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $370,050 |
| NIH project number | 5R01HL149864-05 |
| Project ID | NIH-11001109 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for cardiovascular disease, particularly those with existing conditions related to atherosclerosis.
✕Less likely to help
Patients with non-cardiovascular related health issues or those without risk factors for atherosclerosis may not benefit from this research.
What this research studies
This research investigates the role of vascular calcification as a risk factor for cardiovascular disease (CVD), which is the leading cause of death in the U.S. The study explores how calcification may contribute to the development and progression of atherosclerosis, a condition characterized by the buildup of plaques in the arteries. By examining the effects of tissue-nonspecific alkaline phosphatase (TNAP) and its inhibitors in both animal models and human arteries, the research aims to uncover potential pathways for treatment and prevention. Patients may benefit from insights that could lead to new therapeutic strategies targeting vascular calcification.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart disease by targeting vascular calcification.
How similar studies have gone: Other research has shown promising results in understanding the relationship between vascular calcification and atherosclerosis, suggesting that this approach could yield significant insights.
Where this research is happening
-
New York Inst of Technology
Old Westbury, United States Active
Researchers
- Principal investigator: Savinova, Olga V. — New York Inst of Technology
- Study coordinator: Savinova, Olga V.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.