Understanding how variations in HIV-1 proteins affect the virus's behavior and interactions.
Structural and dynamic traits underlying phenotypic variation in HIV-1 Env
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10643989
This study is looking at how changes in a part of the HIV virus called the envelope glycoprotein affect its ability to infect people and dodge the immune system, which could help scientists create better vaccines and treatments for HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10643989 on ClinicalTrials.gov |
What this research studies
This research investigates the structural and dynamic variations in the HIV-1 envelope glycoprotein (Env) and how these differences influence the virus's ability to infect and evade the immune system. By utilizing advanced techniques like structural mass spectrometry and cryo-electron microscopy, the study aims to uncover how these variations affect antibody binding and the presentation of viral antigens to immune cells. This knowledge could lead to better strategies for vaccine development and treatment options for HIV-1.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1, particularly those with varying responses to current treatments.
Not a fit: Patients who are not infected with HIV-1 or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the understanding of HIV-1 behavior, leading to improved vaccines and therapies for patients living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding HIV-1 dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, KELLY KEISEN — UNIVERSITY OF WASHINGTON
- Study coordinator: LEE, KELLY KEISEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.