Understanding how vaping THC affects the body with and without nicotine
Assessing pharmacokinetic and pharmacodynamic variability of Δ9-tetrahydrocannabinol delivered from vaping products with and without concurrent use of nicotine
This study is looking at how different vaping devices and ways of using them affect how THC from cannabis works in your body, and it's for people who vape THC and want to understand more about its effects and how it interacts with nicotine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project ID | NIH-10868568 on NIH RePORTER |
What this research studies
This research investigates how different vaping devices and user behaviors influence the way THC, the active component in cannabis, is processed in the body. By examining both real-world vaping scenarios and controlled laboratory settings, the study aims to gather data on the pharmacokinetics (how the drug moves through the body) and pharmacodynamics (the effects of the drug) of THC when vaped alone or alongside nicotine. Participants will use their own THC cartridges in a mobile lab setting, allowing for a comprehensive understanding of how these products interact in everyday use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who currently use THC vaping products, particularly those who also use nicotine-containing e-cigarettes.
Not a fit: Patients who do not use THC or nicotine vaping products may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved safety and efficacy guidelines for THC vaping products, benefiting users by providing clearer information on their effects.
How similar studies have performed: Previous research on nicotine vaping has shown significant findings regarding its pharmacokinetics and pharmacodynamics, suggesting that this study may build on established knowledge in a novel context.
Where this research is happening
Buffalo, United States
- Roswell Park Cancer Institute Corp — Buffalo, United States (Active)
Researchers
- Principal investigator: Smith, Danielle — Roswell Park Cancer Institute Corp
- Study coordinator: Smith, Danielle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.