Understanding how vaccines work in protecting African children from malaria
Systems biological assessment of vaccination-induced protective immunity in African children
This study is looking at how young children in Malawi respond to the RTS,S malaria vaccine to see if we can find clues that help us understand how well it works and how long it keeps them safe from malaria.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11062380 on NIH RePORTER |
What this research studies
This research investigates the immune responses of young children in Africa to the RTS,S malaria vaccine, which has shown limited effectiveness. By analyzing blood samples and using advanced computational models, the study aims to identify biological markers that predict how well the vaccine works and how long its protection lasts. The research will focus on children aged 0-11 years in Malawi, leveraging a collaboration with local health initiatives to gather comprehensive data on vaccine responses over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are receiving the RTS,S malaria vaccine in Malawi.
Not a fit: Patients who are older than 11 years or those who are not receiving the RTS,S vaccine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved malaria vaccine strategies that enhance protection for children in Africa.
How similar studies have performed: Previous research has shown promise in understanding vaccine responses through similar biological and computational approaches, indicating potential for success in this study.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Pulendran, Bali — Stanford University
- Study coordinator: Pulendran, Bali
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.