Understanding how vaccines work in children with sickle cell disease
Official title: Immune signatures of vaccine responses in children with sickle cell disease
Funded at Yale University · NIH-10991808 · Data updated 2026-11-12
This study is looking at how kids with sickle cell disease respond to vaccines by checking their immune systems, and it aims to find ways to help them get better protection from vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $598,220 |
| NIH project number | 5R01AI181379-02 |
| Project ID | NIH-10991808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with sickle cell disease, particularly those who may have experienced poor vaccine responses.
✕Less likely to help
Patients without sickle cell disease or those who are not children may not receive any benefit from this research.
What this research studies
This research investigates how children with sickle cell disease respond to vaccines by examining their immune systems. The team will analyze both innate and adaptive immunity, focusing on the molecular changes that occur after vaccination. By using advanced techniques in immunology and systems biology, they aim to identify specific immune signatures that could explain reduced vaccine responses in these children. The findings could lead to better vaccination strategies and improved health outcomes for this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine responses and better health outcomes for children with sickle cell disease.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in similar populations, indicating that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Yildirim, Inci Burcin — Yale University
- Study coordinator: Yildirim, Inci Burcin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.