Understanding how vaccines can protect against certain bacterial infections in children.
Systems Vaccinology Approaches to Define and Predict Immunity in Response to Nontyphoidal Salmonella Conjugate Vaccines
This study is looking at new vaccines to help protect kids from serious infections caused by a type of bacteria called nontyphoidal Salmonella, using special mouse models and smart data analysis to find out what makes vaccines work best.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11017733 on NIH RePORTER |
What this research studies
This research focuses on developing and analyzing new vaccines to protect children from invasive nontyphoidal Salmonella infections. By using advanced mouse models and integrating complex data through bioinformatics and machine learning, the research aims to identify key immune responses that lead to effective vaccination outcomes. The principal investigator, Dr. Scott Baliban, is dedicated to expanding knowledge in systems vaccinology, which will help predict how well vaccines work in preventing infections. The ultimate goal is to improve vaccine strategies for pediatric populations facing these bacterial threats.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are at risk for invasive nontyphoidal Salmonella infections.
Not a fit: Patients who are adults or do not have a risk of exposure to invasive nontyphoidal Salmonella may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that significantly reduce the incidence of serious bacterial infections in children.
How similar studies have performed: Previous research has shown promise in developing effective vaccines against bacterial infections using similar immunological approaches.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Baliban, Scott M. — University of Maryland Baltimore
- Study coordinator: Baliban, Scott M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.