Understanding how vaccines and infections affect B cell responses
Structural interrogation of vaccine- and infection-induced B cell responses
This study is looking at how your immune system's B cells react to vaccines and infections, especially the virus that causes COVID-19, to help improve future vaccines by understanding how these cells recognize the virus in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11023027 on NIH RePORTER |
What this research studies
This research investigates how the immune system's B cells respond to vaccines and infections, particularly focusing on the SARS-CoV-2 virus. By analyzing B cells directly from human samples, the study aims to create detailed maps of how these cells recognize and respond to viral proteins. The researchers will use advanced imaging techniques to visualize these responses at a molecular level, which could lead to better vaccine designs in the future. This approach avoids complications from animal models, allowing for more direct insights into human immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have received a SARS-CoV-2 vaccine or have been infected with the virus.
Not a fit: Patients who have not been vaccinated or infected with SARS-CoV-2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines against rapidly evolving viruses like SARS-CoV-2.
How similar studies have performed: Previous research on influenza has shown that understanding immunodominance can significantly improve vaccine effectiveness, suggesting this approach may also be successful for SARS-CoV-2.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Bajic, Goran — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bajic, Goran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.