Understanding how vaccines affect immune responses in young children
Project 1: Multi-omic endotyping of vaccine response, susceptibility to respiratory infectious disease and asthma
This study looks at how vaccines affect the immune systems of kids under six, exploring how their genes and surroundings play a role, with the hope of finding ways to better protect them from respiratory infections and asthma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11051834 on NIH RePORTER |
What this research studies
This research investigates how vaccines influence the immune development of children under six years old, focusing on the complex interactions between genetics and environmental factors. By using advanced multi-omic profiling techniques, the study aims to identify different immune response patterns, or endotypes, that can help predict susceptibility to respiratory infections and asthma. The goal is to uncover actionable biomarkers that can lead to personalized treatment strategies for young patients, enhancing their immune health and overall well-being.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of six who are receiving vaccinations and may be at risk for respiratory infections or asthma.
Not a fit: Patients over the age of six or those without a history of respiratory infections or asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies and personalized treatments that enhance immune responses in young children, potentially reducing the incidence of respiratory infections and asthma.
How similar studies have performed: Previous research has shown promise in using multi-omic approaches to understand immune responses, suggesting that this methodology could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lasky-Su, Jessica a — Boston Children's Hospital
- Study coordinator: Lasky-Su, Jessica a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.