Understanding how V-ATPases work and their role in diseases
MOLECULAR MECHANISMS OF V-ATPASES: ASSEMBLY, BIOGENESIS, REGULATION, AND FUNCTION
This study is looking at how tiny pumps in our cells, called V-ATPases, work and how they might be linked to diseases like cancer and brain disorders, with the hope that understanding them better could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10875478 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms of V-ATPases, which are essential proton pumps in cells. By purifying these complexes from human cells, the study aims to explore their assembly, regulation, and function using advanced techniques like cryo-electron microscopy. The findings could provide insights into how V-ATPases contribute to various diseases, including cancer and neurodegenerative disorders, and may lead to new therapeutic strategies. Patients may benefit from a better understanding of these mechanisms and potential treatments targeting V-ATPase dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with conditions related to V-ATPase dysfunction, such as cancer, neurodegenerative diseases, or metabolic disorders.
Not a fit: Patients with conditions unrelated to V-ATPase function or those not experiencing any of the associated diseases may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with V-ATPase malfunction.
How similar studies have performed: Other research has shown promising results in understanding V-ATPases, but this approach is innovative and aims to provide deeper insights into their mechanisms.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Fu, Tianmin — Ohio State University
- Study coordinator: Fu, Tianmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.