Understanding how V-ATPases function in cells and their role in diseases
Regulation and Cellular Functions of V-ATPases
This study is looking at special proteins called V-ATPases that help keep cells balanced and healthy, and it's for anyone interested in understanding how these proteins might play a role in diseases like cancer and brain disorders, with the hope of finding new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-11053340 on NIH RePORTER |
What this research studies
This research investigates V-ATPases, which are essential proton pumps in cells that help maintain the acidity of organelles. By studying how these pumps are regulated and how their subunit isoforms function, the research aims to uncover their roles in various diseases, including cancer and neurodegenerative disorders. The approach involves examining the structure and mechanisms of specific protein complexes that interact with V-ATPases, which could lead to targeted therapies. Patients may benefit from insights gained about how V-ATPases contribute to disease processes and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancer, neurodegenerative disorders, or genetic mutations affecting V-ATPase function.
Not a fit: Patients with conditions unrelated to V-ATPase function or those not experiencing the diseases targeted by this research may not benefit.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for conditions like cancer and neurodegenerative diseases.
How similar studies have performed: Other research has shown promising results in targeting cellular mechanisms similar to V-ATPases, indicating potential for success in this area.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Kane, Patricia M — Upstate Medical University
- Study coordinator: Kane, Patricia M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.