Understanding how UV exposure leads to melanoma development
Mechanisms of UV-Mediated Melanoma Development
This study is looking at how our cells fight against melanoma and what goes wrong to cause it, using special mice to see how different kinds of UV light affect skin cancer and how melanin helps, with the goal of finding better ways to prevent and treat melanoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10977300 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms that protect against melanoma and identifies the flaws that lead to tumor formation. By using genetically modified mouse models, the study examines how different types of UV light affect melanoma progression and the role of melanin in this process. The researchers will analyze how DNA damage from UV exposure is repaired and how this impacts tumor growth and response to treatments. The findings aim to enhance our understanding of melanoma and contribute to the development of preventive strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for melanoma, particularly those with a family history of skin cancer or genetic predispositions.
Not a fit: Patients who have already been diagnosed with advanced melanoma may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and treatments for melanoma.
How similar studies have performed: Previous research has shown promising results in understanding melanoma mechanisms, but this approach is exploring novel aspects of UV interaction and melanin's role.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Burd, Christin E — Ohio State University
- Study coordinator: Burd, Christin E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.