Understanding how UV exposure leads to melanoma development
Mechanisms of UV-Mediated Melanoma Development
This study is looking at how our cells can protect us from melanoma and what goes wrong when tumors form, using special mice to see how different kinds of UV light and melanin affect this process, with the hope of finding new ways to prevent or treat melanoma for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10843245 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms that protect against melanoma and identifies the flaws that lead to tumor formation. By studying genetically modified mouse models, the researchers will explore how different types of UV light affect melanoma progression and the role of melanin in this process. The study aims to uncover how UV-induced DNA damage escapes repair, which could provide insights into preventing melanoma. Patients may benefit from findings that could lead to new prevention strategies or treatments for melanoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for melanoma, particularly those with a history of significant sun exposure or genetic predispositions.
Not a fit: Patients who have already been diagnosed with advanced melanoma may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and treatments for melanoma.
How similar studies have performed: Other research has shown success in understanding melanoma mechanisms, but this specific approach focusing on UV exposure and melanin's role is relatively novel.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Burd, Christin E — Ohio State University
- Study coordinator: Burd, Christin E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.