Understanding how Utrophin affects touch sensitivity as we age
Investigating the role for Utrophin in age-related decline of the Merkel lineage
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11098527
This project explores why our sense of touch weakens as we get older, focusing on special skin cells that help us feel gentle touch.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11098527 on ClinicalTrials.gov |
What this research studies
Our sense of touch is vital for everyday activities like eating and communicating. When touch sensitivity declines, it can lead to problems with balance and grip, increasing the risk of falls for older adults. This research looks at specific cells in the skin, called Merkel cells, which are important for gentle touch, and how they change with age. We are particularly interested in how a protein called Utrophin might be involved in maintaining these cells and preventing their decline. Understanding these changes could help us find ways to improve touch sensitivity and quality of life for older individuals.
Who could benefit from this research
Good fit: This research is relevant to adults, particularly those aged 40 to 90 years, experiencing age-related changes in touch sensation.
Not a fit: Patients whose touch deficits are not related to age-related Merkel cell decline may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could lead to new ways to maintain or restore touch sensitivity, improving balance and reducing falls in older adults.
How similar studies have performed: While age-related touch decline is recognized, the specific role of Utrophin in Merkel cell maintenance is a new area of focus for this research.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OWENS, DAVID MICHAEL — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: OWENS, DAVID MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.