Understanding how Usher proteins affect hearing and deafness
Significance of Usher Protein Dynamics in Hair Cell Function and Deafness
['FUNDING_R01'] · WEST VIRGINIA UNIVERSITY · NIH-11049994
This study is looking at how certain proteins in the tiny hair cells in our ears work together and how problems with them can lead to hearing loss, which could help us find new ways to treat deafness.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEST VIRGINIA UNIVERSITY (nih funded) |
| Locations | 1 site (MORGANTOWN, UNITED STATES) |
| Trial ID | NIH-11049994 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind the function and assembly of proteins in hair cells that are crucial for hearing. It focuses on specific proteins known as Usher-1 proteins, which play a vital role in the structure of hair cell stereocilia. By studying how these proteins interact and transport within the cells, the research aims to identify defects that lead to hearing loss. Patients may benefit from insights gained about the genetic causes of deafness and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Usher syndrome or genetic predispositions to hearing loss.
Not a fit: Patients with hearing loss due to non-genetic factors or unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for genetic hearing loss and improve understanding of related vision loss.
How similar studies have performed: Previous research has shown promise in understanding the roles of Usher proteins in hearing, suggesting that this approach could yield valuable insights.
Where this research is happening
MORGANTOWN, UNITED STATES
- WEST VIRGINIA UNIVERSITY — MORGANTOWN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, RONG — WEST VIRGINIA UNIVERSITY
- Study coordinator: LIU, RONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.