Understanding how unconventional RNA translation works
Official title: Computational and experimental approaches for decoding the function and regulation of unconventional RNA translation
Funded at University of Tx Md Anderson Can Ctr · NIH-11010720 · Data updated 2026-11-12
This study is exploring how certain parts of RNA, which we used to think didn’t make proteins, can actually create new proteins that might play important roles in our health and diseases, with the hope of finding new ways to treat illnesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $449,625 |
| NIH project number | 1R35GM156417-01 |
| Project ID | NIH-11010720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cellular growth and signaling, where unconventional RNA translation may play a role.
✕Less likely to help
Patients with conditions unrelated to RNA translation or those not affected by cellular signaling pathways may not benefit from this research.
What this research studies
This research investigates the complex processes of unconventional RNA translation, which can produce new proteins from regions of RNA previously thought to be non-coding. By utilizing advanced computational tools and experimental techniques, the study aims to decode the mechanisms behind these hidden translations and their roles in cellular functions and development. Patients may benefit from insights gained about how these unconventional proteins contribute to health and disease, potentially leading to new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments by uncovering previously unknown proteins that play critical roles in disease.
How similar studies have gone: Other research has shown promising results in understanding unconventional RNA translation, indicating that this approach could yield significant insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Chen, Yiwen — University of Tx Md Anderson Can Ctr
- Study coordinator: Chen, Yiwen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.