Understanding how UBE3B affects brain activity in children with autism
Elucidating the role of the E3 ubiquitin ligase UBE3B in neuronal activity
This study is looking at how a protein called UBE3B affects brain function in children with autism, using a special mouse model to see how it influences brain cell activity and communication, with the hope of understanding more about the challenges faced by kids with autism.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10915553 on NIH RePORTER |
What this research studies
This research investigates the role of the UBE3B protein in brain function, particularly in children with autism spectrum disorder (ASD). By studying a special mouse model that lacks UBE3B, researchers will examine how this protein influences neuronal activity and communication in the brain. The project employs advanced techniques to measure electrical activity in brain cells and to identify the proteins that interact with UBE3B. The goal is to uncover the mechanisms that lead to neurodevelopmental issues associated with ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with autism spectrum disorder or exhibit related developmental challenges.
Not a fit: Patients who do not have autism spectrum disorder or related neurodevelopmental conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into autism and potential therapeutic targets for improving cognitive and communicative functions in affected children.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar proteins in neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Vashisth, Shayal — Ut Southwestern Medical Center
- Study coordinator: Vashisth, Shayal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.