Understanding how U1 snRNP proteins affect gene expression and cancer development
Official title: The role of U1 snRNP proteins in snRNP biogenesis and gene expression regulation
Funded at University of Texas Arlington · NIH-10796664 · Data updated 2026-11-12
This study is looking at how a tiny part of our cells, called U1 snRNP, helps control gene activity and how changes in it might be linked to cancer, so that we can better understand what causes tumors and potentially help patients in the future.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | September 7, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $422,522 |
| NIH project number | 1R15GM152936-01 |
| Project ID | NIH-10796664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with malignancies that exhibit mutations in U1 snRNA affecting splicing.
✕Less likely to help
Patients without cancer or those whose conditions do not involve splicing mutations may not benefit from this research.
What this research studies
This research investigates the role of U1 small nuclear ribonucleoprotein (U1 snRNP) in the regulation of gene expression and its biogenesis. By examining how mutations in U1 snRNA affect splicing and the stability of U1 snRNP, the study aims to uncover mechanisms that may contribute to cancer development. The approach includes analyzing RNA interactions and protein assembly processes that are crucial for proper gene regulation. Patients with cancer may benefit from insights gained into how these molecular processes can lead to tumorigenesis.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer-related gene expression and improving treatment outcomes.
How similar studies have gone: Other research has shown promising results in understanding the role of RNA splicing in cancer, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: So, Byung Ran Ranny — University of Texas Arlington
- Study coordinator: So, Byung Ran Ranny
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.