Understanding how tyrosine phosphatases work in cells
Probing tyrosine phosphatase structure and function
This study is looking at special enzymes that help control important signals in our cells, which can affect diseases like cancer, and it's for anyone interested in how these enzymes work and how we might better understand their role in health and illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10877720 on NIH RePORTER |
What this research studies
This research investigates the role of tyrosine phosphatases, which are enzymes that remove phosphate groups from proteins, thereby regulating important cellular signals. By developing new techniques to study these enzymes, the research aims to uncover how they select their protein targets and how their activity is controlled. This understanding is crucial, as dysregulation of these processes is linked to various diseases, particularly cancers. The research employs high-throughput biochemical methods to analyze these enzymes in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers or other diseases where tyrosine phosphorylation is known to be dysregulated.
Not a fit: Patients with conditions unrelated to tyrosine phosphorylation or those not diagnosed with any disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and other diseases associated with tyrosine phosphatase dysfunction.
How similar studies have performed: While there has been significant research on tyrosine kinases, the exploration of tyrosine phosphatases is less developed, making this approach relatively novel.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Shah, Neel H — Columbia Univ New York Morningside
- Study coordinator: Shah, Neel H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.