Understanding how tyrosine kinases affect liver drug transporters
Regulation of hepatic uptake transporters by tyrosine kinases
This study is looking at how certain proteins in the liver help manage the way your body clears medications, focusing on a specific transporter called OATP1B1, to find ways to improve how drugs work and reduce side effects for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10900586 on NIH RePORTER |
What this research studies
This research investigates how tyrosine kinases regulate liver transporters that are crucial for drug clearance from the body. By focusing on the OATP1B1 transporter, the study aims to uncover how these kinases influence drug interactions and the overall effectiveness of medications. The researchers will identify specific kinases involved and assess their impact on drug accumulation in the liver and plasma. This could lead to better therapeutic strategies and reduced adverse drug reactions for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who are prescribed medications that are affected by liver transporters, particularly those on statins or similar drugs.
Not a fit: Patients who are not taking medications that interact with liver transporters may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug safety and efficacy by minimizing harmful drug interactions.
How similar studies have performed: Previous research has shown that understanding the regulation of drug transporters can lead to significant improvements in patient outcomes, suggesting that this approach has potential for success.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Sprowl, Jason a — State University of New York at Buffalo
- Study coordinator: Sprowl, Jason a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.