Understanding how type-I interferons help the body fight malaria
Type-I Interferons drive cell-autonomous immunity to malaria
['FUNDING_R01'] · UNIVERSITY OF GEORGIA · NIH-11086746
This study is looking at how certain proteins in the liver can help the body fight off malaria, which is caused by a parasite, and it hopes to find new ways to improve treatments for people with malaria.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF GEORGIA (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-11086746 on ClinicalTrials.gov |
What this research studies
This research investigates the role of type-I interferons in the liver's immune response to malaria, a disease caused by the Plasmodium parasite. The study aims to uncover how these interferons can enhance the body's ability to eliminate the parasite from liver cells, which is crucial for preventing severe malaria. By focusing on the mechanisms of autophagy, the research seeks to identify new therapeutic strategies that could improve malaria treatment and prevention. Patients may benefit from insights that could lead to more effective anti-malarial therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk of malaria infection, particularly those living in endemic regions.
Not a fit: Patients who are not at risk of malaria or those who have already been treated for malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's natural defenses against malaria, potentially reducing the disease's severity and improving patient outcomes.
How similar studies have performed: Other research has shown promise in utilizing immune responses to combat malaria, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
ATHENS, UNITED STATES
- UNIVERSITY OF GEORGIA — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KURUP, SAM — UNIVERSITY OF GEORGIA
- Study coordinator: KURUP, SAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.