Understanding how type I interferons are produced in lupus
Upstream drivers of type I interferons in lupus
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11096045
This study is looking at why some people with lupus have high levels of certain proteins in their immune system, by comparing their immune cells to those of healthy people, to help us better understand what causes lupus symptoms and flare-ups.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11096045 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the chronic production of type I interferons in patients with systemic lupus erythematosus (SLE). By analyzing immune cells such as neutrophils and monocytes from SLE patients and comparing them to healthy individuals, the researchers aim to identify the triggers that lead to interferon production. The study employs advanced technologies, including ultrasensitive protein detection and nucleic acid sequencing, to gather detailed insights into the molecular pathways involved. This comprehensive approach could significantly enhance our understanding of lupus and its flares.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus, particularly those experiencing chronic symptoms.
Not a fit: Patients without a diagnosis of systemic lupus erythematosus or those with other autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing lupus and reducing disease flares.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in lupus, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUSTELIN, TOMAS M — UNIVERSITY OF WASHINGTON
- Study coordinator: MUSTELIN, TOMAS M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.