Understanding how type I interferons affect brain injury recovery
Official title: Mechanisms of type I interferon neuropathology following traumatic brain injury
Funded at University of Iowa · NIH-10930897 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain help fight inflammation and damage after a traumatic brain injury, with the goal of finding new ways to help people recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | September 19, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $452,462 |
| NIH project number | 5R01NS127844-02 |
| Project ID | NIH-10930897 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have experienced an acute traumatic brain injury.
✕Less likely to help
Patients with chronic neurological conditions unrelated to traumatic brain injury may not benefit from this research.
What this research studies
This research investigates the role of type I interferons in the brain's immune response following traumatic brain injury (TBI). It aims to understand how these interferons influence inflammation and neurodegeneration, which can lead to long-term cognitive issues. By studying the activation of microglial cells, the primary immune cells in the brain, the research seeks to identify potential therapeutic targets to improve recovery outcomes for individuals with TBI. The approach includes analyzing the molecular signaling pathways involved in the brain's response to injury.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve recovery and reduce long-term complications for patients with traumatic brain injuries.
How similar studies have gone: Previous research has shown promising results in targeting neuroinflammation in brain injuries, suggesting that this approach could be effective.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Newell, Elizabeth — University of Iowa
- Study coordinator: Newell, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.